Usti (Ustecky) region is situated in the northwest of the Czech Republic , along the border with Federal Republic of Germany. To the northeast it borders with Liberec region, to the west with Karlovy Vary region and a small part of Pilsen region. To the south it borders with Central Bohemian region. The north border of the region is also the border with German Saxony region.

Along the border with Germany, the area is enclosed by Krusne hory, Labske piskovce and Luzicke hory mountain ranges. The southeast of the region consists of flatland, from which rises Ceske stredohori. Majority of the region belongs to the Elbe drainage area, which is the most important waterway in the Czech Republic and which enables water transport among the Czech cities situated on the Elbe and Vltava rivers and places in Germany, as well as the North Sea port Hamburg. The rivers Ohre and Bilina cross west part of the region. Decin Township has the river Ploucnice.

The area of Usti region is divided to seven townships with 354 municipalities. Considering the population, the region places fifth in the Czech Republic. The population density is higher that the state average and is different from township to township. Area with the highest density is the lignite coalfield near Krusne hory mountains. The area of 5,335 km2 takes 6.8% of the Czech Republic overall area.

The industrial importance of the region is given by the rich mineral resources, especially the lignite coalfields and the power and chemical industries connected with the coalfields. The economical activities, in the past aimed especially at the coal mining, power industry and chemistry had and still has negative influence on the environment. Structural changes during the last couple years caused the number of jobs in the industry decrease. Services industry was not able to offer enough job possibilities, which resulted in the increased rate of unemployment. Agriculture in the region is mainly famous for vegetables and hops growing.

Through the townships of Teplice and Litomerice runs an important international road E 55 connecting the north and south of Europe. Near Lovosice, the road changes to D 8 highway. Next important road connection is the road along Krusne hory to Germany, thru Chomutov and Louny to Prague.

The main train connection is the international line from Germany through Usti nad Labem to Prague. Owing to its rich settlement history, Usti region has many historical sights. Among the most popular are the baroque castle in Duchcov, Romanesque rotunda on Rip, gothic church in Most, monastery in Osek and the castles Ploskovice and Libochovice. In the regional gallery in Litomerice exceptional painting collections can be found. From the natural beauties, the most famous is the National Park Ceske Svycarsko with well-known Pravcicka brana.